The COPD Companion
(PEP in your Breath, 2024) What cause COPD
Available at: What causes COPD? COPD risk factors & etiology
COPD Risk factors
Understanding the risk factors associated with COPD is crucial for prevention and early intervention.
Primary Risk Factors:
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Smoking: The predominant cause of COPD is long-term cigarette smoking. The risk escalates with the duration and intensity of smoking. Notably, exposure to secondhand smoke also elevates the risk.
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Environmental Exposures:
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Occupational Hazards: Chronic exposure to dust, chemical fumes, and vapors in workplaces can damage the lungs, contributing to COPD development.
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Indoor Air Pollution: In low- and middle-income countries, using biomass fuels (such as wood, animal dung, and crop residues) or coal for cooking and heating in poorly ventilated spaces leads to high levels of indoor air pollution, increasing COPD risk.
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Genetic Factors: A rare genetic disorder known as alpha-1 antitrypsin deficiency can lead to lung deterioration and increase susceptibility to COPD, even in non-smokers.
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Age and Gender: Individuals over 65 and females are at a higher risk of developing COPD.
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Respiratory Infections: A history of frequent childhood respiratory infections can impair lung development, increasing the risk of COPD in later life.
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Asthma: People with asthma may have a higher risk of developing COPD.

(TP research Tool, 2022)COPD triggers Available at: chronic-obstructive-pulmonary-disease-copd-mc-slide5.png (720×540)
Potential risk factors:
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Nutritional Status:
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A low Body Mass Index (BMI) or malnutrition can lead to decreased lung function, making individuals more vulnerable to COPD.
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Obesity may place an additional burden on the respiratory system, worsening breathlessness.
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Mental Health: Long-term anxiety, depression, or chronic stress can contribute to systemic inflammation, potentially accelerating COPD progression.
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Respiratory Allergens: Continuous exposure to allergens such as pollen, pet dander, and mold can exacerbate lung inflammation and airway sensitivity.
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Chronic Lung Infections or Inflammation
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A history of tuberculosis (TB) can increasing susceptibility to COPD.
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Recurrent bronchitis or pneumonia can lead to structural changes in the airways, making them more prone to damage.
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Urban Air Pollution: Living in highly polluted urban areas, particularly those with elevated levels of PM2.5 or NO₂, can increase the risk of COPD.
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Chronic Sinusitis: Persistent sinus issues can lead to long-term airway inflammation, worsening symptoms in COPD patients.